This is exactly the type of situation where it pays to address this question early on in the appraisal report, all through pg 1. You need to prep the reader in advance for what you're going to do on pg 2. You don't want to just spring it on them at the last minute when they get to your SC analysis and comp selection.
Not directed to the OP or their specific example because I don't know exactly how they wrote their report. But in general
Be specific in the neighborhood analysis. If there is a trend for remodel/flips or redevelopment in the area then that's worth some attention. If the composition includes a wide variety of ages, sizes and condition then that's worth a comment. If there is short term rental activity then comment on that. Even if your subject doesn't fit into any of these other trends they might still be of effect on the value or marketability.
If you think the property is worth about as much in its current configuration as if vacant then say that directly. If the existing combo is worth a little more but might not be for long then that brings in the question of remaining economic life. for example:
The most profitable use in the "as is" condition is the existing use, but at the current rate of redevelopment for the area the REL of these improvements may be less than 10 years.
REL is an economic construct that includes consideration of both the physical condition and the economic environment. Regardless of the condition of the improvements, if they don't add to the value as if vacant then it is what it is.
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In the sales comparison, pay attention to the financing and the types of buyers. If some or most of the comps are being purchased by contractors or developers and they're not using SFR financing then that indicates to both their intentions AND which property attributes they're valuing. In terms of redevelopment, a 1200sf on 6000sf lot isn't the same as a 1200sf on a 10,000sf lot. The lot is the thing, not the SFR. It will be real common in my region for the listings to include comments like "the value is in the land" or some such when that's the case.
OTOH, if most of the comps are being purchased with SFR financing then that indicates to then using those properties in their current configuration and not as redevelopment-bait. Sooner or later we're all running into datasets where some of these properties are going one way and some are going the other way. A comment might be instructive:
"of these sales, it appears ~15% of them were marketed and purchased for redevelopment". You're not ignoring the minority trend but you're also not fixating on it. Don't lose sight of the point that what we're looking for in the value conclusion is most probable.
As CGMinn noted, lot configuration can be a big issue, too. If the requisite side setbacks for a 40ft wide lot are 5ft each then the bldg envelope can't exceed 30sf width. That might cut into the ability to run a 3car garage side-by-side. They might have to switch up to a 2+tandem design to get 3 cars into a garage. A wider/shorter lot of 6000sf might be more valuable to a developer than a narrower/deeper lot of 6000sf even though the overall sizes are similar. A parcel with alley access might be more valuable than one with no vehicular access to the rear.