Histoplasmosis primarily affects a person's lungs, and its symptoms vary greatly. The vast majority of infected people are asymptomatic (have no apparent ill effects) or they experience symptoms so mild they do not seek medical attention. If symptoms do occur, they will usually start within 3 to 17 days after exposure, with an average of 10 days. Histoplasmosis can appear as a mild, flu-like respiratory illness and has a combination of symptoms, including malaise (a general ill feeling), fever, chest pain, dry or nonproductive cough, headache, loss of appetite, shortness of breath, joint and muscle pains, chills, and hoarseness. A chest X-ray can reveal distinct markings on an infected person's lungs. Chronic lung disease due to histoplasmosis resembles tuberculosis and can worsen over months or years. The most severe and rare form of this disease is disseminated histoplasmosis, which involves spreading of the fungus to other organs outside the lungs.
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